Elgarhy, L. H. and El-Tatawy, R. A. and Ali, D. A. Mohammed and Anber, D. M. Abo (2021) Evaluation of Intralesional Injection of 5-fluorouracil in Treatment of Vitiligo. Journal of Advances in Medicine and Medical Research, 33 (6). pp. 11-16. ISSN 2456-8899
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Abstract
Background: Vitiligo is a chronic cutaneous disease characterized by depigmented patches that leave psychological impact on the patients. New treatment modalities have been developed to improve the results vitiligo with less side effects.
Objective: To evaluate intralesional injection of 5-fluorouracil in treatment of vitiligo.
Patients and Methods: The study included 20 localized stable vitiligo patients. Each patient was treated with intralesional injection of 5-fluorouracil every 2 weeks for 3 sessions followed by narrow band sessions twice weekly for 3 months.
Results: There was statistically significant repigmentation after treatment with intralesional 5-FU (mean of 50.30 ± 34.60, P value =0.001 Wilcoxon signed ranks test between before and after). 55% of patients showed >50% repigmentation. after 3 months therapy. Side effects were minimal and transient.
Conclusion: Intralesional injection of 5-FU is safe and effective in the treatment of vitiligo.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5-fluorouracil; carbon dioxide laser; vitiligo |
| Subjects: | SCI Archives > Medical Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 11 Nov 2022 04:48 |
| Last Modified: | 12 Jul 2024 06:57 |
| URI: | http://science.classicopenlibrary.com/id/eprint/145 |
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